TLQP-21 modulate inflammation and fibrosis in a model of ards
نویسندگان
چکیده
Objectives To explore the therapeutic role of a short analog of TLQP-21 (JMV5656) in an experimental model of ARDS. Methods C57/BL6 mice received an instillation of 0.1 M HCl, 2.5 ml/kg into the right bronchus. They were treated with TLQP-21 0.6 mg/kg ip or vehicle control, 2 days before and on the same day of HCl challenge. Respiratory system compliance, blood gas analysis and differential cell counts in a selective bronchoalveolar lavage (BAL) were determined 24 h after HCl. In a parallel experiment mice were observed for 14 days to assess epithelial damage and lung fibrosis.
منابع مشابه
Thymoquinone restores liver fibrosis and improves oxidative stress status in a lipopolysaccharide-induced inflammation model in rats
Objective: Liver fibrosis is the primary sign of chronic liver injury induced by various causes. Thymoquinone (TQ) is the major ingredient of Nigella sativa with several beneficial effects on the body. In the present study, we aimed to investigate the effect of TQ on liver fibrosis in a lipopolysaccharide (LPS)-induced inflammation in male rats. Materials and methods: Fifty male Wistar rats wer...
متن کاملVGF-derived peptide, TLQP-21, regulates food intake and body weight in Siberian hamsters.
The Siberian hamster survives winter by decreasing food intake and catabolizing abdominal fat reserves, resulting in a sustained, profound loss of body weight. VGF gene expression is photoperiodically regulated in the hypothalamus with significantly higher expression in lean Siberian hamsters. The aim of this study was to investigate the role of VGF in regulating these seasonal cycles by determ...
متن کاملTLQP-21 Protects Human Umbilical Vein Endothelial Cells against High-Glucose-Induced Apoptosis by Increasing G6PD Expression
Hyperglycemia causes oxidative stress that could damage vascular endothelial cells, leading to cardiovascular complications. The Vgf gene was identified as a nerve growth factor-responsive gene, and its protein product, VGF, is characterized by the presence of partially cleaved products. One of the VGF-derived peptides is TLQP-21, which is composed of 21 amino acids (residues 556-576). Past stu...
متن کامل0995. Aspirin reduces neutrophilic pulmonary inflammation in a human model of acute respiratory distress syndrome induced by inhaled lipopolysaccharide
Introduction Acute respiratory distress syndrome (ARDS) is characterized by damage to the alveolar epithelial-endothelial barrier resulting in neutrophil influx and pulmonary oedema. The activation of platelet and secondary capture of neutrophils may play an important role in propagation of inflammation in ARDS [1]. Various animal studies have shown that aspirin therapy reduces pulmonary oedema...
متن کاملPharmacological and Biochemical Characterization of TLQP-21 Activation of a Binding Site on CHO Cells
VGF is a propeptide of 617 amino acids expressed throughout the central and the peripheral nervous system. VGF and peptides derived from its processing have been found in dense core vesicles and are released from neuronal and neuroendocrine cells via the regulated secretory pathway. Among VGF-derived neuropeptides, TLQP-21 (VGF556-576) has raised a huge interest and is one of most studied. TLQP...
متن کامل